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Understanding Tuskegee

In 1932, the Public Health Service, working with the Tuskegee Institute, began a study to record the natural history of syphilis in hopes of justifying treatment programs for blacks. It was called the “Tuskegee Study of Untreated Syphilis in the Negro Male.”

The study initially involved 600 black men – 399 with syphilis, 201 who did not have the disease. The study was conducted without the benefit of patients’ informed consent.

Researchers told the men they were being treated for “bad blood,” a local term used to describe several ailments, including syphilis, anemia, and fatigue. In truth, they did not receive the proper treatment needed to cure their illness.

In exchange for taking part in the study, the men received free medical exams, free meals, and burial insurance. Although originally projected to last 6 months, the study actually went on for 40 years.

What Went Wrong

In July 1972, an Associated Press story about the Tuskegee Study caused a public outcry that led the Assistant Secretary for Health and Scientific Affairs to appoint an Ad Hoc Advisory Panel to review the study. The panel had nine members from the fields of medicine, law, religion, labor, education, health administration, and public affairs.

The panel found that the men had agreed freely to be examined and treated. However, there was no evidence that researchers had informed them of the study or its real purpose. In fact, the men had been misled and had not been given all the facts required to provide informed consent.

The men were never given adequate treatment for their disease. Even when penicillin became the drug of choice for syphilis in 1947, researchers did not offer it to the subjects. The advisory panel found nothing to show that subjects were ever given the choice of quitting the study, even when this new, highly effective treatment became widely used.

What’s Changed

After the Tuskeegee Experiment, regulations were passed in 1974 that required researchers to get voluntary informed consent from all persons taking part in studies done or funded by the Department of Health and Human Services. They also required that all Department of Health and Human Services-supported studies using human subjects be reviewed by Institutional Review Boards, which read study protocols and decide whether they meet ethical standards.

While these new laws do not erase these past wrongs, it can prevent them from happening again. The rules and policies for human subjects research are continually reviewed to assure that respect for human dignity will occur in current clinical research. These new rules and policies were applied to the clinical trials on human subjects that led to the development of vaccines.


The advisory panel concluded that the Tuskegee Study was “ethically unjustified”–the knowledge gained was sparse when compared with the risks the study posed for its subjects. In October 1972, the panel advised stopping the study at once. A month later, the Assistant Secretary for Health and Scientific Affairs announced the end of the Tuskegee Study.

In the summer of 1973, a class-action lawsuit was filed on behalf of the study participants and their families. In 1974, a $10 million out-of-court settlement was reached. As part of the settlement, the U.S. government promised to give lifetime medical benefits and burial services to all living participants. The Tuskegee Health Benefit Program (THBP) was established to provide these services.

In 1975, wives, widows and offspring were added to the program. In 1995, the program was expanded to include health as well as medical benefits. The Centers for Disease Control and Prevention was given responsibility for the program, where it remains today in the National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention.

The last study participant died in January 2004. The last widow receiving THBP benefits died in January 2009. There are 11 offspring currently receiving medical and health benefits.

Frequently Asked Questions

Visit the CDC’s Tuskegee FAQ page

I want to hear information from doctors and medical professionals of color:

View video

I want to learn more about the Tuskegee Experiment:

Visit the Tuskegee University’s website

Tuskegee family members and the vaccine:

View an article and short video: Family of Tuskegee Syphilis Study participant say they’ll take COVID-19 vaccine but understand the distrust.

Will President Obama get the vaccine?

Yes. President Obama has said that he will get the vaccine. You can watch him here.

Will Reverend Al Sharpton get the vaccine?

Yes. Reverend Sharpton will get the vaccine. You can watch him here.

NAACP Town Hall

The NAACP held a town hall to discuss and educate the public about the COVID-19 vaccine. You can watch it here.

¿Cómo puedo obtener una cita para recibir la vacuna del COVID-19?

Staying Safe

Can I Get Vaccinated if I’m Not a U.S. Citizen?

Vaccinators cannot require proof of residency to get the vaccine. Yes, if you are part of a group that is currently eligible, you can get vaccinated.

President Biden has stated that all people in the U.S. – regardless of their immigration status – can get the vaccine. The U.S. Department of Homeland Security also supports vaccine access for undocumented immigrants.

The United States Department of Homeland Security (DHS) states that “DHS is committed to ensuring that every individual who needs a vaccine can get one, regardless of their immigration status. U.S. Immigration and Customs Enforcement (ICE) and U.S. Customs and Border Protection will not conduct enforcement operations at or near vaccine distribution sites or clinics. Consistent with ICE’s long-standing sensitive locations policy, ICE does not and will not carry out enforcement operations at or near health care facilities, such as hospitals, doctors’ offices, accredited health clinics, and emergent or urgent care facilities, except in the most extraordinary of circumstances.”

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